Upsher Management Company (“Upsher” or “UMC”) is a fifth-generation single-family office based in New York, NY and Jackson, WY. Built on a legacy in the pharmaceutical industry, Upsher has been active and investing in health and life sciences for almost a century. The firm invests in disruptive innovation, deploying capital across early-stage venture capital, growth equity, core private equity, and in public markets. Each decade, the firm researches and targets durable, decade-long themes to complement the heritage healthcare strategy. Starting in 2020, UMC identified geopolitical turbulence as an investable theme, pursuing industries where the firm has a unique edge and insight to connect the dots from geopolitics, to geoeconomics, to the capital markets. The primary sectors underlying the ‘Geopolitical Investing’ program include Defense Innovation, Energy Security, Applied AI & Computing Power, and Advanced Manufacturing.