Upsher Management Company (“Upsher” or “UMC”) is a fifth-generation single-family office based in New York, NY and Jackson, WY. Built on a legacy in the pharmaceutical industry, Upsher has been active and investing in health and life sciences for almost a century. The firm invests in disruptive innovation, deploying capital across early-stage venture capital, growth equity, core private equity, and in public markets. Each decade, the firm researches and targets durable, decade-long themes to complement the heritage healthcare strategy. Starting in 2020, UMC identified geopolitical turbulence as an investable theme, pursuing industries where the firm has a unique edge and insight to connect the dots from geopolitics, to geoeconomics, to the capital markets. The primary sectors underlying the ‘Geopolitical Investing’ program include National Security & Defense, Energy Security, Advanced Manufacturing, and Applied AI & Computing Power.